It is difficult to know exactly when the shift from gelatine to agar occurred. As often happens for scientific breakthroughs, agar was likely adopted incrementally alongside the use of other growth media. In 1913, for example, the first diagnosis of Serratia marcescens as a human pathogen was made by growing it on agar as well as on potatoes.
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As for the national debt, the benefits of immigration are only likely to accrue with time. Later generations of immigrants tend to pay more in taxes as educational attainment and incomes rise, according to the Cato Institute’s report, which called children of immigrants “the most potent fiscal engine this country has ever seen.” Should Trump’s immigration crackdown cause a sustained decline in new entries, that engine will be much less powerful than it could have been.